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I didn't understand the first two paragraphs of 'Subtypes and genetic causes'.

Willow ( talk) 16:02, 6 January 2008 (UTC) Reply

OK, I put it first and re-wrote it slightly.

The 'History' seems to interrupt the flow of the article - I would either put it first or last in the article.

Pigmentosa aside, I think the damage may only be visible only microscopically, on the level of cells or between cells, so the macroscopic anatomy of the ear or eye might not be that useful.

I completely agree, although I'd need to find/make such diagrams, which could be hard for me.

What do you think about an appropriate diagram of the eye or ear in the 'Symtoms and subtypes' section, rather than the genetic chart, which seems more appropriate to the 'Genetics' section?.

I need to read up more on the specific cellular and inter-cellular pathologies of Usher syndrome I'm worried that this sentence is not accurate as is, or at least may be slightly misleading.

The hearing impairment associated with Usher syndrome is better understood: damaged hair cells in the cochlea of the inner ear inhibit electrical impulses from reaching the brain.

It's both, no? The rate at which you go blind varies with the clinical subtype.

Why is Usher's severity defined by deafness and not blindness?.

Presumably that syndrome could occur anywhere, but maybe people have only studied it there, or maybe there's a locally high concentration of people with the mutated gene living there.

Why are the people born with Usher III in Finland and Birmingham?.

I only know the few studies I mentioned (US, Germany, Scandinavia) but they are probably more perhaps from France or England? Willow ( talk) 16:02, 6 January 2008 (UTC) Reply.

I suppose we don't have figures for Usher syndrome from any other part of the world?.

That is information that will interest them in particular. Many of the readers coming to this page will be people with the disease or people who now know someone with it.

The 'potential cures' paragraph I have just created should probably be expanded.

is that OK? Willow ( talk) 16:02, 6 January 2008 (UTC) Reply

Removed definition of autosomal recessive, but kept explanation of parental thing.

Again, important in the body of the article, but not necessarily in the lead as it is not specific to Usher syndrome itself.

I wonder if it is necessary to explain what recessive means in the lead.

I guess they're not different enough clinically? Probably nowadays people might refer directly to the mutated gene.

This seemed a little odd to me - are the forms not different enough to have different names?

Depending on which gene is mutated, the syndrome takes different forms three main sub-types are recognized, denoted Usher I, II and III in order of decreasing severity.

OK, I moved that, along with the definition of 'syndrome'.

Fascinating as this tidbit is, I think it belongs in the body of the article, not the lead.

The qualifier pigmentosa reflects the fact that clumps of pigment may be visible by an ophthalmoscope in advanced stages of degeneration.

Is that better? Willow ( talk) 16:02, 6 January 2008 (UTC) Reply.

Perhaps something a little more specific?

'gene therapy seems promising' - As someone with a disease for which 'gene therapy seems promising', that phrase rings empty, I can tell you.

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